Here's an example of PowerPoint (or something like it) taken to the edge. At that edge they find humor, style and make a point. (Actually, I'd argue that it makes a number of points.)
It's called "Le Grand Content." It a fast-moving animated presentation with intersections, connections, graphs and diagrams that answers some of the "big questions." And it's funny. Smart funny.
There's teenage poetry, coffee, a heart full of regret, rejection, your mom, hobbits, beer, the pursuit of happiness, and hamster death.
It plays with many of the conventions of presentations including the standard shapes & animations of PowerPoint.
It's probably available on YouTube and other places now, but I'll send you to the source so can can read more about the background (plus the video quality is better). They list the very unusual blog INDEXED which is done on those wonderful 3X5 file cards as an inspiration. Check that out too.